Quantitative Proteomics of Synaptosomal Fractions in a Rat Overexpressing Human DISC1 Gene Indicates Profound Synaptic Dysregulation in the Dorsal Striatum

Disrupted-in-schizophrenia 1 (DISC1) is a key protein involved in behavioral processes and various mental disorders, including schizophrenia and major depression. A transgenic rat overexpressing non-mutant human DISC1, modeling aberrant proteostasis of the DISC1 protein, displays behavioral, biochem...

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Detalles Bibliográficos
Autores principales: Sialana, Fernando J., Wang, An-Li, Fazari, Benedetta, Kristofova, Martina, Smidak, Roman, Trossbach, Svenja V., Korth, Carsten, Huston, Joseph P., de Souza Silva, Maria A., Lubec, Gert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808171/
https://www.ncbi.nlm.nih.gov/pubmed/29467617
http://dx.doi.org/10.3389/fnmol.2018.00026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808171/
https://www.ncbi.nlm.nih.gov/pubmed/29467617
http://dx.doi.org/10.3389/fnmol.2018.00026

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