Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling

Background: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have emerged as a promising experimental tool for translational heart research and drug development. However, their usability as a human adult cardiomyocyte model is limited by their functional immaturity. Our aim is...

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Detalles Bibliográficos
Autores principales: Koivumäki, Jussi T., Naumenko, Nikolay, Tuomainen, Tomi, Takalo, Jouni, Oksanen, Minna, Puttonen, Katja A., Lehtonen, Šárka, Kuusisto, Johanna, Laakso, Markku, Koistinaho, Jari, Tavi, Pasi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808345/
https://www.ncbi.nlm.nih.gov/pubmed/29467678
http://dx.doi.org/10.3389/fphys.2018.00080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808345/
https://www.ncbi.nlm.nih.gov/pubmed/29467678
http://dx.doi.org/10.3389/fphys.2018.00080

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