Target Identification and Mode of Action of Four Chemically Divergent Drugs against Ebolavirus Infection

[Image: see text] Here, we show that four chemically divergent approved drugs reported to inhibit Ebolavirus infection, benztropine, bepridil, paroxetine and sertraline, directly interact with the Ebolavirus glycoprotein. Binding of these drugs destabilizes the protein, suggesting that this may be t...

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Detalles Bibliográficos
Autores principales: Ren, Jingshan, Zhao, Yuguang, Fry, Elizabeth E., Stuart, David I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808380/
https://www.ncbi.nlm.nih.gov/pubmed/29272110
http://dx.doi.org/10.1021/acs.jmedchem.7b01249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808380/
https://www.ncbi.nlm.nih.gov/pubmed/29272110
http://dx.doi.org/10.1021/acs.jmedchem.7b01249

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