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Target Identification and Mode of Action of Four Chemically Divergent Drugs against Ebolavirus Infection
[Image: see text] Here, we show that four chemically divergent approved drugs reported to inhibit Ebolavirus infection, benztropine, bepridil, paroxetine and sertraline, directly interact with the Ebolavirus glycoprotein. Binding of these drugs destabilizes the protein, suggesting that this may be t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808380/ https://www.ncbi.nlm.nih.gov/pubmed/29272110 http://dx.doi.org/10.1021/acs.jmedchem.7b01249 |