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Enhancing Evolutionary Couplings with Deep Convolutional Neural Networks
While genes are defined by sequence, in biological systems a protein’s function is largely determined by its three-dimensional structure. Evolutionary information embedded within multiple sequence alignments provides a rich source of data for inferring structural constraints on macromolecules. Still...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808454/ https://www.ncbi.nlm.nih.gov/pubmed/29275173 http://dx.doi.org/10.1016/j.cels.2017.11.014 |