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Enhancing Evolutionary Couplings with Deep Convolutional Neural Networks

While genes are defined by sequence, in biological systems a protein’s function is largely determined by its three-dimensional structure. Evolutionary information embedded within multiple sequence alignments provides a rich source of data for inferring structural constraints on macromolecules. Still...

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Detalles Bibliográficos
Autores principales: Liu, Yang, Palmedo, Perry, Ye, Qing, Berger, Bonnie, Peng, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808454/
https://www.ncbi.nlm.nih.gov/pubmed/29275173
http://dx.doi.org/10.1016/j.cels.2017.11.014