TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R-loops

The shelterin protein TRF2 assembles protective T-loops at chromosome ends by stimulating intramolecular invasion of the telomeric G-rich ssDNA overhang into the duplex telomeric array. The other shelterin factor TRF1 is thought to mainly facilitate telomeric dsDNA replication without directly parti...

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Detalles Bibliográficos
Autores principales: Lee, Yong Woo, Arora, Rajika, Wischnewski, Harry, Azzalin, Claus M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808845/
https://www.ncbi.nlm.nih.gov/pubmed/29358759
http://dx.doi.org/10.1038/s41594-017-0021-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808845/
https://www.ncbi.nlm.nih.gov/pubmed/29358759
http://dx.doi.org/10.1038/s41594-017-0021-5

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