ErbB2-positive mammary tumors can escape PI3K-p110α loss through downregulation of the Pten tumor suppressor

Breast cancer is the most common cancer among women and 30% will be diagnosed with an ErbB2-positive cancer. Forty percent of ErbB2-positive breast tumors have an activating mutation in p110α, a catalytic subunit of phosphoinositide 3-kinase (PI3K). Clinical and experimental data show that breast tu...

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Detalles Bibliográficos
Autores principales: Simond, Alexandra M., Rao, Trisha, Zuo, Dongmei, Zhao, Jean J., Muller, William J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808977/
https://www.ncbi.nlm.nih.gov/pubmed/28783168
http://dx.doi.org/10.1038/onc.2017.264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808977/
https://www.ncbi.nlm.nih.gov/pubmed/28783168
http://dx.doi.org/10.1038/onc.2017.264

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