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ErbB2-positive mammary tumors can escape PI3K-p110α loss through downregulation of the Pten tumor suppressor
Breast cancer is the most common cancer among women and 30% will be diagnosed with an ErbB2-positive cancer. Forty percent of ErbB2-positive breast tumors have an activating mutation in p110α, a catalytic subunit of phosphoinositide 3-kinase (PI3K). Clinical and experimental data show that breast tu...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808977/ https://www.ncbi.nlm.nih.gov/pubmed/28783168 http://dx.doi.org/10.1038/onc.2017.264 |