Single cell on-chip whole genome amplification via micropillar arrays for reduced amplification bias

Single cell whole genome amplification is susceptible to amplification biases that impact the accuracy of single cell sequencing data. To address this, we have developed a microfluidic device for the isolation and purification of genomic DNA from individual cells. The device uses a micropillar array...

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Detalles Bibliográficos
Autores principales: Tian, Harvey C., Benitez, Jaime J., Craighead, Harold G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809021/
https://www.ncbi.nlm.nih.gov/pubmed/29432426
http://dx.doi.org/10.1371/journal.pone.0191520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809021/
https://www.ncbi.nlm.nih.gov/pubmed/29432426
http://dx.doi.org/10.1371/journal.pone.0191520

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