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High throughput protease profiling comprehensively defines active site specificity for thrombin and ADAMTS13
We have combined random 6 amino acid substrate phage display with high throughput sequencing to comprehensively define the active site specificity of the serine protease thrombin and the metalloprotease ADAMTS13. The substrate motif for thrombin was determined by >6,700 cleaved peptides, and was...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809430/ https://www.ncbi.nlm.nih.gov/pubmed/29434246 http://dx.doi.org/10.1038/s41598-018-21021-9 |