The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts

NFκB activation and regulated cell death are important in tissue homeostasis, inflammation and pathogenesis. Here we show the role of the p55TNFR–IKK2l–Ripk3 axis in the regulation of synovial fibroblast homeostasis and pathogenesis in TNF-mediated mouse models of arthritis. Mesenchymal-specific p55...

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Detalles Bibliográficos
Autores principales: Armaka, Marietta, Ospelt, Caroline, Pasparakis, Manolis, Kollias, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809454/
https://www.ncbi.nlm.nih.gov/pubmed/29434332
http://dx.doi.org/10.1038/s41467-018-02935-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809454/
https://www.ncbi.nlm.nih.gov/pubmed/29434332
http://dx.doi.org/10.1038/s41467-018-02935-4

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