A human endothelial cell-based recycling assay for screening of FcRn targeted molecules

Albumin and IgG have remarkably long serum half-lives due to pH-dependent FcRn-mediated cellular recycling that rescues both ligands from intracellular degradation. Furthermore, increase in half-lives of IgG and albumin-based therapeutics has the potential to improve their efficacies, but there is a...

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Detalles Bibliográficos
Autores principales: Grevys, Algirdas, Nilsen, Jeannette, Sand, Kine M. K., Daba, Muluneh B., Øynebråten, Inger, Bern, Malin, McAdam, Martin B., Foss, Stian, Schlothauer, Tilman, Michaelsen, Terje E., Christianson, Gregory J., Roopenian, Derry C., Blumberg, Richard S., Sandlie, Inger, Andersen, Jan Terje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809500/
https://www.ncbi.nlm.nih.gov/pubmed/29434196
http://dx.doi.org/10.1038/s41467-018-03061-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809500/
https://www.ncbi.nlm.nih.gov/pubmed/29434196
http://dx.doi.org/10.1038/s41467-018-03061-x

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