A Trimeric HIV-1 Envelope gp120 Immunogen Induces Potent and Broad Anti-V1V2 Loop Antibodies against HIV-1 in Rabbits and Rhesus Macaques

Trimeric HIV-1 envelope (Env) immunogens are attractive due to their ability to display quaternary epitopes targeted by broadly neutralizing antibodies (bNAbs) while obscuring unfavorable epitopes. Results from the RV144 trial highlighted the importance of vaccine-induced HIV-1 Env V1V2-directed ant...

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Detalles Bibliográficos
Autores principales: Jones, Andrew T., Chamcha, Venkateswarlu, Kesavardhana, Sannula, Shen, Xiaoying, Beaumont, David, Das, Raksha, Wyatt, Linda S., LaBranche, Celia C., Stanfield-Oakley, Sherry, Ferrari, Guido, Montefiori, David C., Moss, Bernard, Tomaras, Georgia D., Varadarajan, Raghavan, Amara, Rama Rao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809733/
https://www.ncbi.nlm.nih.gov/pubmed/29237847
http://dx.doi.org/10.1128/JVI.01796-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809733/
https://www.ncbi.nlm.nih.gov/pubmed/29237847
http://dx.doi.org/10.1128/JVI.01796-17

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