CXCR7 participates in CXCL12-mediated migration and homing of leukemic and normal hematopoietic cells

CXCR4 was the first receptor identified for CXCL12, but a second receptor, CXCR7, has also been described and its function in hematopoietic cells remains unknown. By inhibition of CXCR4 and/or CXCR7, we showed that CXCR7 participates in normal CD34(+) and U937 cell migration and prevents downregulat...

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Autores principales: Melo, Rita de Cassia Carvalho, Ferro, Karla Priscila Viera, Duarte, Adriana da Silva Santos, Olalla Saad, Sara Teresinha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810108/
https://www.ncbi.nlm.nih.gov/pubmed/29433559
http://dx.doi.org/10.1186/s13287-017-0765-1
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author Melo, Rita de Cassia Carvalho
Ferro, Karla Priscila Viera
Duarte, Adriana da Silva Santos
Olalla Saad, Sara Teresinha
author_facet Melo, Rita de Cassia Carvalho
Ferro, Karla Priscila Viera
Duarte, Adriana da Silva Santos
Olalla Saad, Sara Teresinha
author_sort Melo, Rita de Cassia Carvalho
collection PubMed
description CXCR4 was the first receptor identified for CXCL12, but a second receptor, CXCR7, has also been described and its function in hematopoietic cells remains unknown. By inhibition of CXCR4 and/or CXCR7, we showed that CXCR7 participates in normal CD34(+) and U937 cell migration and prevents downregulation of CXCR4 by CXCL12 stimulation. In addition, CXCR7 contributes to homing of acute myeloid leukemia and normal progenitor cells to the bone marrow and spleen of NOD/SCID mice. In summary, this study shows an essential role of CXCR7, together with CXCR4, in the control of normal and malignant hematopoietic cell migration and homing induced by CXCL12.
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spelling pubmed-58101082018-02-16 CXCR7 participates in CXCL12-mediated migration and homing of leukemic and normal hematopoietic cells Melo, Rita de Cassia Carvalho Ferro, Karla Priscila Viera Duarte, Adriana da Silva Santos Olalla Saad, Sara Teresinha Stem Cell Res Ther Letter CXCR4 was the first receptor identified for CXCL12, but a second receptor, CXCR7, has also been described and its function in hematopoietic cells remains unknown. By inhibition of CXCR4 and/or CXCR7, we showed that CXCR7 participates in normal CD34(+) and U937 cell migration and prevents downregulation of CXCR4 by CXCL12 stimulation. In addition, CXCR7 contributes to homing of acute myeloid leukemia and normal progenitor cells to the bone marrow and spleen of NOD/SCID mice. In summary, this study shows an essential role of CXCR7, together with CXCR4, in the control of normal and malignant hematopoietic cell migration and homing induced by CXCL12. BioMed Central 2018-02-12 /pmc/articles/PMC5810108/ /pubmed/29433559 http://dx.doi.org/10.1186/s13287-017-0765-1 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter
Melo, Rita de Cassia Carvalho
Ferro, Karla Priscila Viera
Duarte, Adriana da Silva Santos
Olalla Saad, Sara Teresinha
CXCR7 participates in CXCL12-mediated migration and homing of leukemic and normal hematopoietic cells
title CXCR7 participates in CXCL12-mediated migration and homing of leukemic and normal hematopoietic cells
title_full CXCR7 participates in CXCL12-mediated migration and homing of leukemic and normal hematopoietic cells
title_fullStr CXCR7 participates in CXCL12-mediated migration and homing of leukemic and normal hematopoietic cells
title_full_unstemmed CXCR7 participates in CXCL12-mediated migration and homing of leukemic and normal hematopoietic cells
title_short CXCR7 participates in CXCL12-mediated migration and homing of leukemic and normal hematopoietic cells
title_sort cxcr7 participates in cxcl12-mediated migration and homing of leukemic and normal hematopoietic cells
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810108/
https://www.ncbi.nlm.nih.gov/pubmed/29433559
http://dx.doi.org/10.1186/s13287-017-0765-1
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