SF3B1 deficiency impairs human erythropoiesis via activation of p53 pathway: implications for understanding of ineffective erythropoiesis in MDS

BACKGROUND: SF3B1 is a core component of splicing machinery. Mutations in SF3B1 are frequently found in myelodysplastic syndromes (MDS), particularly in patients with refractory anemia with ringed sideroblasts (RARS), characterized by isolated anemia. SF3B1 mutations have been implicated in the path...

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Detalles Bibliográficos
Autores principales: Huang, Yumin, Hale, John, Wang, Yaomei, Li, Wei, Zhang, Shijie, Zhang, Jieying, Zhao, Huizhi, Guo, Xinhua, Liu, Jing, Yan, Hongxia, Yazdanbakhsh, Karina, Huang, Gang, Hillyer, Christopher D., Mohandas, Narla, Chen, Lixiang, Sun, Ling, An, Xiuli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810112/
https://www.ncbi.nlm.nih.gov/pubmed/29433555
http://dx.doi.org/10.1186/s13045-018-0558-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810112/
https://www.ncbi.nlm.nih.gov/pubmed/29433555
http://dx.doi.org/10.1186/s13045-018-0558-8

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