Poly-arginine R18 and R18D (D-enantiomer) peptides reduce infarct volume and improves behavioural outcomes following perinatal hypoxic-ischaemic encephalopathy in the P7 rat

We examined the neuroprotective efficacy of the poly-arginine peptide R18 and its D-enantiomer R18D in a perinatal hypoxic-ischaemic (HI) model in P7 Sprague-Dawley rats. R18 and R18D peptides were administered intraperitoneally at doses of 30, 100, 300 or 1000 nmol/kg immediately after HI (8% O(2)/...

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Detalles Bibliográficos
Autores principales: Edwards, Adam B., Cross, Jane L., Anderton, Ryan S., Knuckey, Neville W., Meloni, Bruno P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810179/
https://www.ncbi.nlm.nih.gov/pubmed/29426351
http://dx.doi.org/10.1186/s13041-018-0352-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810179/
https://www.ncbi.nlm.nih.gov/pubmed/29426351
http://dx.doi.org/10.1186/s13041-018-0352-0

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