In the Absence of Central pre-B Cell Receptor Selection, Peripheral Selection Attempts to Optimize the Antibody Repertoire by Enriching for CDR-H3 Y101

Sequential developmental checkpoints are used to “optimize” the B cell antigen receptor repertoire by minimizing production of autoreactive or useless immunoglobulins and enriching for potentially protective antibodies. The first and apparently most impactful checkpoint requires μHC to form a functi...

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Detalles Bibliográficos
Autores principales: Khass, Mohamed, Blackburn, Tessa, Elgavish, Ada, Burrows, Peter D., Schroeder, Harry W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810287/
https://www.ncbi.nlm.nih.gov/pubmed/29472919
http://dx.doi.org/10.3389/fimmu.2018.00120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810287/
https://www.ncbi.nlm.nih.gov/pubmed/29472919
http://dx.doi.org/10.3389/fimmu.2018.00120

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