Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer’s Disease

Microtubule (MT) associated protein tau is abnormally hyperphosphorylated and aggregated into paired helical filaments (PHFs), which manifest as neurofibrillary tangles (NFTs) in the brains of individuals with Alzheimer’s disease (AD) and related tauopathies. Hyperphosphorylation and truncation of t...

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Detalles Bibliográficos
Autores principales: Zhou, Yan, Shi, Jianhua, Chu, Dandan, Hu, Wen, Guan, Zongyu, Gong, Cheng-Xin, Iqbal, Khalid, Liu, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810298/
https://www.ncbi.nlm.nih.gov/pubmed/29472853
http://dx.doi.org/10.3389/fnagi.2018.00027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810298/
https://www.ncbi.nlm.nih.gov/pubmed/29472853
http://dx.doi.org/10.3389/fnagi.2018.00027

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