Inhibition of Siah2 Ubiquitin Ligase by Vitamin K3 Attenuates Chronic Myeloid Leukemia Chemo-Resistance in Hypoxic Microenvironment

BACKGROUND: A hypoxic microenvironment is associated with resistance to tyrosine kinase inhibitors (TKIs) and a poor prognosis in chronic myeloid leukemia (CML). The E3 ubiquitin ligase Siah2 plays a vital role in the regulation of hypoxia response, as well as in leukemogenesis. However, the role of...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Jixian, Lu, Ziyuan, Xiao, Yajuan, He, Bolin, Pan, Chengyun, Zhou, Xuan, Xu, Na, Liu, Xiaoli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Lab/In Vitro Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810368/
https://www.ncbi.nlm.nih.gov/pubmed/29400343
http://dx.doi.org/10.12659/MSM.908553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810368/
https://www.ncbi.nlm.nih.gov/pubmed/29400343
http://dx.doi.org/10.12659/MSM.908553

Ejemplares similares