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Inhibition of Siah2 Ubiquitin Ligase by Vitamin K3 Attenuates Chronic Myeloid Leukemia Chemo-Resistance in Hypoxic Microenvironment

BACKGROUND: A hypoxic microenvironment is associated with resistance to tyrosine kinase inhibitors (TKIs) and a poor prognosis in chronic myeloid leukemia (CML). The E3 ubiquitin ligase Siah2 plays a vital role in the regulation of hypoxia response, as well as in leukemogenesis. However, the role of...

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Detalles Bibliográficos
Autores principales:	Huang, Jixian, Lu, Ziyuan, Xiao, Yajuan, He, Bolin, Pan, Chengyun, Zhou, Xuan, Xu, Na, Liu, Xiaoli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Scientific Literature, Inc. 2018
Materias:	Lab/In Vitro Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810368/ https://www.ncbi.nlm.nih.gov/pubmed/29400343 http://dx.doi.org/10.12659/MSM.908553

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