Impaired cohesion and homologous recombination during replicative aging in budding yeast

The causal relationship between genomic instability and replicative aging is unclear. We reveal here that genomic instability at the budding yeast ribosomal DNA (rDNA) locus increases during aging, potentially due to the reduced cohesion that we uncovered during aging caused by the reduced abundance...

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Detalles Bibliográficos
Autores principales: Pal, Sangita, Postnikoff, Spike D., Chavez, Myrriah, Tyler, Jessica K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810620/
https://www.ncbi.nlm.nih.gov/pubmed/29441364
http://dx.doi.org/10.1126/sciadv.aaq0236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810620/
https://www.ncbi.nlm.nih.gov/pubmed/29441364
http://dx.doi.org/10.1126/sciadv.aaq0236

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