Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice

Gammaherpesviruses encode proteins with homology to the cellular purine metabolic enzyme formyl-glycinamide-phosphoribosyl-amidotransferase (FGARAT), but the role of these viral FGARATs (vFGARATs) in the pathogenesis of a natural host has not been investigated. We report a novel role for the ORF75A...

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Detalles Bibliográficos
Autores principales: Van Skike, Nick D., Minkah, Nana K., Hogan, Chad H., Wu, Gary, Benziger, Peter T., Oldenburg, Darby G., Kara, Mehmet, Kim-Holzapfel, Deborah M., White, Douglas W., Tibbetts, Scott A., French, Jarrod B., Krug, Laurie T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811070/
https://www.ncbi.nlm.nih.gov/pubmed/29390024
http://dx.doi.org/10.1371/journal.ppat.1006843

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811070/
https://www.ncbi.nlm.nih.gov/pubmed/29390024
http://dx.doi.org/10.1371/journal.ppat.1006843

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