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Developing diazirine-based chemical probes to identify histone modification ‘readers’ and ‘erasers’

Post translational modifications (PTMs, e.g., phosphorylation, acetylation and methylation) of histone play important roles in regulating many fundamental cellular processes such as gene transcription, DNA replication and damage repair. While ‘writer’ and ‘eraser’ enzymes modify histones by catalyzi...

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Detalles Bibliográficos
Autores principales: Yang, Tangpo, Liu, Zheng, Li, Xiang David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811097/
https://www.ncbi.nlm.nih.gov/pubmed/29560188
http://dx.doi.org/10.1039/c4sc02328e