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A combination of polyunsaturated fatty acid, nonribosomal peptide and polyketide biosynthetic machinery is used to assemble the zeamine antibiotics

The zeamines are a unique group of antibiotics produced by Serratia plymuthica RVH1 that contain variable hybrid peptide–polyketide moieties connected to a common pentaamino-hydroxyalkyl chain. They exhibit potent activity against a broad spectrum of Gram-positive and Gram-negative bacteria. Here we...

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Detalles Bibliográficos
Autores principales: Masschelein, Joleen, Clauwers, Charlien, Awodi, Ufedo R., Stalmans, Karen, Vermaelen, Wesley, Lescrinier, Eveline, Aertsen, Abram, Michiels, Chris, Challis, Gregory L., Lavigne, Rob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811116/
https://www.ncbi.nlm.nih.gov/pubmed/29560178
http://dx.doi.org/10.1039/c4sc01927j