Highly enantioselective access to diketopiperazines via cinchona alkaloid catalyzed Michael additions

Michael addition reactions of triketopiperazine (TKP) derivatives to enones, mediated by a cinchona alkaloid-derived catalyst, deliver products in high yield and enantiomeric ratio (er). Use of unsaturated ester, nitrile or sulfone partners gives bridged hydroxy-diketopiperazine (DKP) products resul...

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Detalles Bibliográficos
Autores principales: Cabanillas, Alejandro, Davies, Christopher D., Male, Louise, Simpkins, Nigel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811140/
https://www.ncbi.nlm.nih.gov/pubmed/29560222
http://dx.doi.org/10.1039/c4sc03218g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811140/
https://www.ncbi.nlm.nih.gov/pubmed/29560222
http://dx.doi.org/10.1039/c4sc03218g

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