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Highly enantioselective access to diketopiperazines via cinchona alkaloid catalyzed Michael additions

Michael addition reactions of triketopiperazine (TKP) derivatives to enones, mediated by a cinchona alkaloid-derived catalyst, deliver products in high yield and enantiomeric ratio (er). Use of unsaturated ester, nitrile or sulfone partners gives bridged hydroxy-diketopiperazine (DKP) products resul...

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Detalles Bibliográficos
Autores principales:	Cabanillas, Alejandro, Davies, Christopher D., Male, Louise, Simpkins, Nigel S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2015
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811140/ https://www.ncbi.nlm.nih.gov/pubmed/29560222 http://dx.doi.org/10.1039/c4sc03218g

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