mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4

The mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth that is commonly deregulated in human diseases. Here we find that mTORC1 controls a transcriptional program encoding amino acid transporters and metabolic enzymes through a mechanism also used to regulate prote...

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Detalles Bibliográficos
Autores principales: Park, Yeonwoo, Reyna-Neyra, Andrea, Philippe, Lucas, Thoreen, Carson C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811220/
https://www.ncbi.nlm.nih.gov/pubmed/28494858
http://dx.doi.org/10.1016/j.celrep.2017.04.042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811220/
https://www.ncbi.nlm.nih.gov/pubmed/28494858
http://dx.doi.org/10.1016/j.celrep.2017.04.042

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