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The Model Structures of the Complement Component 5a Receptor (C5aR) Bound to the Native and Engineered (h)C5a
The interaction of (h)C5a with C5aR, previously hypothesized to involve a “two-site” binding, (i) recognition of the bulk of (h)C5a by the N-terminus (NT) of C5aR (“site1”), and (ii) recognition of C-terminus (CT) of (h)C5a by the extra cellular surface (ECS) of the C5aR (“site2”). However, the phar...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811428/ https://www.ncbi.nlm.nih.gov/pubmed/29440703 http://dx.doi.org/10.1038/s41598-018-21290-4 |