Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models

Enhancers regulate gene expression and have been linked with disease pathogenesis. Little is known about enhancers that regulate human disease-associated genes in primary cells relevant for pathogenesis. Here we use BAC transgenics and genome editing to dissect, in vivo and in primary immune cells,...

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Detalles Bibliográficos
Autores principales: Sokhi, Upneet K., Liber, Mark P., Frye, Laura, Park, Sungho, Kang, Kyuho, Pannellini, Tania, Zhao, Baohong, Norinsky, Rada, Ivashkiv, Lionel B., Gong, Shiaoching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811492/
https://www.ncbi.nlm.nih.gov/pubmed/29440643
http://dx.doi.org/10.1038/s41467-018-03081-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811492/
https://www.ncbi.nlm.nih.gov/pubmed/29440643
http://dx.doi.org/10.1038/s41467-018-03081-7

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