Cargando…

Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models

Enhancers regulate gene expression and have been linked with disease pathogenesis. Little is known about enhancers that regulate human disease-associated genes in primary cells relevant for pathogenesis. Here we use BAC transgenics and genome editing to dissect, in vivo and in primary immune cells,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sokhi, Upneet K., Liber, Mark P., Frye, Laura, Park, Sungho, Kang, Kyuho, Pannellini, Tania, Zhao, Baohong, Norinsky, Rada, Ivashkiv, Lionel B., Gong, Shiaoching
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811492/ https://www.ncbi.nlm.nih.gov/pubmed/29440643 http://dx.doi.org/10.1038/s41467-018-03081-7

Ejemplares similares

Distinct Inflammatory Macrophage Populations Sequentially Infiltrate Bone‐to‐Tendon Interface Tissue After Anterior Cruciate Ligament (ACL) Reconstruction Surgery in Mice
por: Fujii, Takayuki, et al.
Publicado: (2022)

Regulation of Age-associated B cells by IRF5 in systemic autoimmunity
por: Manni, Michela, et al.
Publicado: (2018)

MEF2C regulates osteoclastogenesis and pathologic bone resorption via c-FOS
por: Fujii, Takayuki, et al.
Publicado: (2021)

Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors
por: Zhao, Baohong, et al.
Publicado: (2011)

Tumor Necrosis Factor dynamically regulates the mRNA stabilome in rheumatoid arthritis fibroblast-like synoviocytes
por: Loupasakis, Konstantinos, et al.
Publicado: (2017)

Early-onset autoimmune disease due to a heterozygous loss-of-function mutation in TNFAIP3 (A20)
por: Duncan, Christopher J A, et al.
Publicado: (2018)

A20/TNFAIP3 heterozygosity predisposes to behavioral symptoms in a mouse model for neuropsychiatric lupus
por: Daems, C., et al.
Publicado: (2019)

TNFAIP3(A20) genetic alterations in AIDS-related lymphomas
por: Giulino, Lisa, et al.
Publicado: (2010)

Identification of a Novel Mutation in TNFAIP3 in a Family With Poly-Autoimmunity
por: Rossi, Marianna Nicoletta, et al.
Publicado: (2022)

Mutation analysis of the TNFAIP3 in A20 haploinsufficiency: A case report
por: Yan, Mei, et al.
Publicado: (2021)

RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes
por: Foldi, Julia, et al.
Publicado: (2016)

TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J
por: Zhao, Baohong, et al.
Publicado: (2012)

A20 (TNFAIP3) Deletion in Epstein-Barr Virus-Associated Lymphoproliferative Disorders/Lymphomas
por: Ando, Midori, et al.
Publicado: (2013)

Deletion of the TNFAIP3/A20 gene detected by FICTION analysis in classical Hodgkin lymphoma
por: Nomoto, Junko, et al.
Publicado: (2012)

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20
por: Drennan, Michael B., et al.
Publicado: (2016)

Juvenile onset autoinflammatory disease due to a novel mutation in TNFAIP3 (A20)
por: Sato, Shuzo, et al.
Publicado: (2018)

A critical region of A20 unveiled by missense TNFAIP3 variations that lead to autoinflammation
por: El Khouri, Elma, et al.
Publicado: (2023)

Susceptibility of TNFAIP8, TNFAIP8L1, and TNFAIP2 Gene Polymorphisms on Cancer Risk: A Comprehensive Review and Meta-Analysis of Case–Control Studies
por: Bhowmik, Khokon Kanti, et al.
Publicado: (2022)

Role of deleterious single nucleotide variants in the coding regions of TNFAIP3 for Japanese autoimmune hepatitis with cirrhosis
por: Higuchi, Takashi, et al.
Publicado: (2019)

A20 (Tnfaip3) Deficiency in Myeloid Cells Protects against Influenza A Virus Infection
por: Maelfait, Jonathan, et al.
Publicado: (2012)

Functional Effect of Polymorphisms in the Promoter of TNFAIP3 (A20) in Acute Pancreatitis in the Han Chinese Population
por: Liu, Yugang, et al.
Publicado: (2014)

A dominantly-inherited Behcet-like disorder caused by haploinsufficiency of the TNFAIP3/A20 protein
por: Zhou, Q, et al.
Publicado: (2015)

Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice
por: Van Damme, Karel F. A., et al.
Publicado: (2023)

TNFAIP8 family gene expressions in the mouse tail intervertebral disc injury model
por: Tian, Zuozhen, et al.
Publicado: (2020)

RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis
por: Li, Susan, et al.
Publicado: (2022)

IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation
por: Kang, Kyuho, et al.
Publicado: (2019)

Correction: A20 (Tnfaip3) Deficiency in Myeloid Cells Protects against Influenza A Virus Infection
por: Maelfait, Jonathan, et al.
Publicado: (2012)

Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early onset autoinflammatory syndrome
por: Zhou, Qing, et al.
Publicado: (2015)

The roles of TNFAIP2 in cancers and infectious diseases
por: Jia, Lin, et al.
Publicado: (2018)

TNFAIP8: Inflammation, Immunity and Human Diseases
por: Niture, Suryakant, et al.
Publicado: (2019)

TNFAIP3 is anti-inflammatory in the retinal vasculature
por: Liu, Li, et al.
Publicado: (2022)

Correlation Between TNFAIP2 Gene Polymorphism and Prediction/Prognosis for Gastric Cancer and Its Effect on TNFAIP2 Protein Expression
por: Guo, Fang, et al.
Publicado: (2020)

Meta-Analysis of the TNFAIP3 Region in Psoriasis Reveals a Risk Haplotype that is Distinct from Other Autoimmune Diseases
por: Nititham, Joanne, et al.
Publicado: (2014)

Mouse Transgenesis in a Single Locus with Independent Regulation for Multiple Fluorophores
por: Dougherty, Joseph D., et al.
Publicado: (2012)

Type I IFNs and TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation
por: Park, Sung Ho, et al.
Publicado: (2017)

New mechanisms of action and signaling by TNF-α
por: Ivashkiv, Lionel B
Publicado: (2012)

TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma
por: Schmitz, Roland, et al.
Publicado: (2009)

A20 (TNFAIP3) Alleviates CVB3-Induced Myocarditis via Inhibiting NF-κB Signaling
por: Gui, Jun, et al.
Publicado: (2012)

Remission of CVB3-induced myocarditis with Astragaloside IV treatment requires A20 (TNFAIP3) up-regulation
por: Gui, Jun, et al.
Publicado: (2015)

Case Report: A Novel TNFAIP3 Mutation Causing Haploinsufficiency of A20 With a Lupus-Like Phenotype
por: Shaheen, Zachary R., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_slgpub21k3ta56hujs65n7rnna