Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice

Vaccine delivery is an essential element for the development of mucosal vaccine, but it remains to be investigated how physical barriers such as mucus and cilia affect vaccine delivery efficacy. Previously, we reported that C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE) targeted...

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Detalles Bibliográficos
Autores principales: Suzuki, Hidehiko, Nagatake, Takahiro, Nasu, Ayaka, Lan, Huangwenxian, Ikegami, Koji, Setou, Mitsutoshi, Hamazaki, Yoko, Kiyono, Hiroshi, Yagi, Kiyohito, Kondoh, Masuo, Kunisawa, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811541/
https://www.ncbi.nlm.nih.gov/pubmed/29440671
http://dx.doi.org/10.1038/s41598-018-21120-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811541/
https://www.ncbi.nlm.nih.gov/pubmed/29440671
http://dx.doi.org/10.1038/s41598-018-21120-7

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