Salt-bridge modulates differential calcium-mediated ligand binding to integrin α1- and α2-I domains

Integrins are transmembrane cell-extracellular matrix adhesion receptors that impact many cellular functions. A subgroup of integrins contain an inserted (I) domain within the α–subunits (αI) that mediate ligand recognition where function is contingent on binding a divalent cation at the metal ion d...

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Detalles Bibliográficos
Autores principales: Brown, Kyle L., Banerjee, Surajit, Feigley, Andrew, Abe, Hanna, Blackwell, Timothy S., Pozzi, Ambra, Hudson, Billy G., Zent, Roy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811549/
https://www.ncbi.nlm.nih.gov/pubmed/29440721
http://dx.doi.org/10.1038/s41598-018-21231-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811549/
https://www.ncbi.nlm.nih.gov/pubmed/29440721
http://dx.doi.org/10.1038/s41598-018-21231-1

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