Cargando…
Salt-bridge modulates differential calcium-mediated ligand binding to integrin α1- and α2-I domains
Integrins are transmembrane cell-extracellular matrix adhesion receptors that impact many cellular functions. A subgroup of integrins contain an inserted (I) domain within the α–subunits (αI) that mediate ligand recognition where function is contingent on binding a divalent cation at the metal ion d...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811549/ https://www.ncbi.nlm.nih.gov/pubmed/29440721 http://dx.doi.org/10.1038/s41598-018-21231-1 |