Structure of prothrombin in the closed form reveals new details on the mechanism of activation

The clotting factor prothrombin exists in equilibrium between closed and open conformations, but the physiological role of these forms remains unclear. As for other allosteric proteins, elucidation of the linkage between molecular transitions and function is facilitated by reagents stabilized in eac...

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Detalles Bibliográficos
Autores principales: Chinnaraj, Mathivanan, Chen, Zhiwei, Pelc, Leslie A., Grese, Zachary, Bystranowska, Dominika, Di Cera, Enrico, Pozzi, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811608/
https://www.ncbi.nlm.nih.gov/pubmed/29440720
http://dx.doi.org/10.1038/s41598-018-21304-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811608/
https://www.ncbi.nlm.nih.gov/pubmed/29440720
http://dx.doi.org/10.1038/s41598-018-21304-1

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