CRISPR/Cas9, a new approach to successful knockdown of ABCB1/P-glycoprotein and reversal of chemosensitivity in human epithelial ovarian cancer cell line

OBJECTIVE(S): Multidrug resistance (MDR) is a major obstacle in the successful chemotherapy of ovarian cancer. Inhibition of P-glycoprotein (P-gp), a member of ATP-binding cassette (ABC) transporters, is a well-known strategy to overcome MDR in cancer. The aim of this study was to investigate the ef...

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Detalles Bibliográficos
Autores principales: Norouzi-Barough, Leyla, Sarookhani, Mohammadreza, Salehi, Rasoul, Sharifi, Mohammadreza, Moghbelinejad, Sahar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811757/
https://www.ncbi.nlm.nih.gov/pubmed/29456815
http://dx.doi.org/10.22038/IJBMS.2017.25145.6230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811757/
https://www.ncbi.nlm.nih.gov/pubmed/29456815
http://dx.doi.org/10.22038/IJBMS.2017.25145.6230

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