Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor

Theoretical models of G protein-coupled receptor (GPCR) concentration-response relationships often assume an agonist producing a single functional response via a single active state of the receptor. These models have largely been analysed assuming steady-state conditions. There is now much experimen...

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Detalles Bibliográficos
Autores principales: Bridge, L.J., Mead, J., Frattini, E., Winfield, I., Ladds, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811930/
https://www.ncbi.nlm.nih.gov/pubmed/29337260
http://dx.doi.org/10.1016/j.jtbi.2018.01.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811930/
https://www.ncbi.nlm.nih.gov/pubmed/29337260
http://dx.doi.org/10.1016/j.jtbi.2018.01.010

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