Conservation of alternative splicing in sodium channels reveals evolutionary focus on release from inactivation and structural insights into gating

KEY POINTS: Sodium channels are critical for supporting fast action potentials in neurons; even mutations which cause small changes in sodium channel activity can have devastating consequences for the function of the nervous system. Alternative splicing also changes the activity of sodium channels,...

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Detalles Bibliográficos
Autores principales: Liavas, A., Lignani, G., Schorge, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Neuroscience ‐ Cellular/Molecular
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811987/
https://www.ncbi.nlm.nih.gov/pubmed/28621020
http://dx.doi.org/10.1113/JP274693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811987/
https://www.ncbi.nlm.nih.gov/pubmed/28621020
http://dx.doi.org/10.1113/JP274693

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