Trovafloxacin attenuates neuroinflammation and improves outcome after traumatic brain injury in mice

BACKGROUND: Trovafloxacin is a broad-spectrum antibiotic, recently identified as an inhibitor of pannexin-1 (Panx1) channels. Panx1 channels are important conduits for the adenosine triphosphate (ATP) release from live and dying cells that enhances the inflammatory response of immune cells. Elevated...

Descripción completa

Detalles Bibliográficos
Autores principales: Garg, Charu, Seo, Joon Ho, Ramachandran, Jayalakshmi, Loh, Ji Meng, Calderon, Frances, Contreras, Jorge E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812039/
https://www.ncbi.nlm.nih.gov/pubmed/29439712
http://dx.doi.org/10.1186/s12974-018-1069-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812039/
https://www.ncbi.nlm.nih.gov/pubmed/29439712
http://dx.doi.org/10.1186/s12974-018-1069-9

Ejemplares similares