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Trovafloxacin attenuates neuroinflammation and improves outcome after traumatic brain injury in mice

BACKGROUND: Trovafloxacin is a broad-spectrum antibiotic, recently identified as an inhibitor of pannexin-1 (Panx1) channels. Panx1 channels are important conduits for the adenosine triphosphate (ATP) release from live and dying cells that enhances the inflammatory response of immune cells. Elevated...

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Detalles Bibliográficos
Autores principales:	Garg, Charu, Seo, Joon Ho, Ramachandran, Jayalakshmi, Loh, Ji Meng, Calderon, Frances, Contreras, Jorge E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812039/ https://www.ncbi.nlm.nih.gov/pubmed/29439712 http://dx.doi.org/10.1186/s12974-018-1069-9

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