Antitumor effects of metformin via indirect inhibition of protein phosphatase 2A in patients with endometrial cancer

OBJECTIVE: Metformin, an antidiabetic drug, inhibits the endometrial cancer cell growth in vivo by improving the insulin resistance; however, its mechanism of action is not completely understood. Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase associated with insulin resistance and t...

Descripción completa

Detalles Bibliográficos
Autores principales: Hanawa, Shinsuke, Mitsuhashi, Akira, Shozu, Makio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812621/
https://www.ncbi.nlm.nih.gov/pubmed/29444159
http://dx.doi.org/10.1371/journal.pone.0192759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812621/
https://www.ncbi.nlm.nih.gov/pubmed/29444159
http://dx.doi.org/10.1371/journal.pone.0192759

Ejemplares similares