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Enhanced viral-mediated cochlear gene delivery in adult mice by combining canal fenestration with round window membrane inoculation

Cochlear gene therapy holds promise for the treatment of genetic deafness. Assessing its impact in adult murine models of hearing loss, however, has been hampered by technical challenges that have made it difficult to establish a robust method to deliver transgenes to the mature murine inner ear. He...

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Detalles Bibliográficos
Autores principales:	Yoshimura, Hidekane, Shibata, Seiji B., Ranum, Paul T., Smith, Richard J. H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812997/ https://www.ncbi.nlm.nih.gov/pubmed/29445157 http://dx.doi.org/10.1038/s41598-018-21233-z

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