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Progesterone Receptor Membrane Component 1 suppresses the p53 and Wnt/β-catenin pathways to promote human pluripotent stem cell self-renewal

Progesterone receptor membrane component 1 (PGRMC1) is a multifunctional heme-binding protein involved in various diseases, including cancers and Alzheimer’s disease. Previously, we generated two monoclonal antibodies (MAbs) 108-B6 and 4A68 against surface molecules on human pluripotent stem cells (...

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Detalles Bibliográficos
Autores principales: Kim, Ji Yea, Kim, So Young, Choi, Hong Seo, Kim, Min Kyu, Lee, Hyun Min, Jang, Young-Joo, Ryu, Chun Jeih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813096/
https://www.ncbi.nlm.nih.gov/pubmed/29445107
http://dx.doi.org/10.1038/s41598-018-21322-z