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Reverse Translation in PBPK and QSP: Going Backwards in Order to Go Forward With Confidence
Significant events have taken place shaping the recent industrialization of physiologically based pharmacokinetic in vitro–in vivo extrapolation (PBPK‐IVIVE) use in drug development. Due to our knowledge gaps about drug‐independent systems parameters, there are limitations in the use of purely IVIVE...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813098/ https://www.ncbi.nlm.nih.gov/pubmed/29023678 http://dx.doi.org/10.1002/cpt.904 |