Cargando…
The mechanism of attenuation of epithelial‐mesenchymal transition by a phosphodiesterase 5 inhibitor via renal klotho expression
Phosphodiesterase‐5 (PDE‐5) inhibitors induces vasodilation in several organs by blocking cyclic GMP (guanosine monophosphate) degradation. However, the existence of alternative mechanism of action in case of an impaired nitric oxide (NO) system remains controversial. Previous studies suggested that...
Autores principales: | Han, Seung T, Kim, Jae S, Lee, Jun Y, Kim, Min K, Yoo, Jin S, Han, Byoung G, Choi, Seung O, Yang, Jae W |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813144/ https://www.ncbi.nlm.nih.gov/pubmed/29029361 http://dx.doi.org/10.1111/1440-1681.12872 |
Ejemplares similares
-
Klotho Regulates Epithelial-to-Mesenchymal Transition In Vitro via Wnt/β-Catenin Pathway and Attenuates Chronic Allograft Dysfunction in a Rat Renal Transplant Model
por: Li, Xiao-Jun, et al.
Publicado: (2021) -
RhoGDI2 promotes epithelial-mesenchymal transition via induction of Snail in gastric cancer cells
por: Cho, Hee Jun, et al.
Publicado: (2014) -
Phosphodiesterase Inhibitor Improves Renal Tubulointerstitial Hypoxia of the Diabetic Rat Kidney
por: Sun, Hui-Kyoung, et al.
Publicado: (2012) -
Klotho prevents epithelial–mesenchymal transition through Egr-1 downregulation in diabetic kidney disease
por: Li, Yang, et al.
Publicado: (2021) -
Silibinin attenuates radiation-induced intestinal fibrosis and reverses epithelial-to-mesenchymal transition
por: Kim, Joong Sun, et al.
Publicado: (2017)