Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and finding synergistic drug combinations

Hsp70 is a promising anti-cancer target. Our JG-98 series of Hsp70 inhibitors show anti-cancer activities affecting both cancer cells and tumor-associated macrophages. They disrupt Hsp70 interaction with a co-chaperone Bag3 and affect signaling pathways important for cancer development. Due to a pri...

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Detalles Bibliográficos
Autores principales: Yaglom, Julia A., Wang, Yongmei, Li, Amy, Li, Zhenghu, Monti, Stephano, Alexandrov, Ilya, Lu, Xiongbin, Sherman, Michael Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813176/
https://www.ncbi.nlm.nih.gov/pubmed/29445088
http://dx.doi.org/10.1038/s41598-017-14900-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813176/
https://www.ncbi.nlm.nih.gov/pubmed/29445088
http://dx.doi.org/10.1038/s41598-017-14900-0

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