Integration of mechanistic and pharmacokinetic information to derive oral reference dose and margin‐of‐exposure values for hexavalent chromium

The current US Environmental Protection Agency (EPA) reference dose (RfD) for oral exposure to chromium, 0.003 mg kg(−1) day(−1), is based on a no‐observable‐adverse‐effect‐level from a 1958 bioassay of rats exposed to ≤25 ppm hexavalent chromium [Cr(VI)] in drinking water. EPA characterizes the con...

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Detalles Bibliográficos
Autores principales: Thompson, Chad M., Kirman, Christopher R., Hays, Sean M., Suh, Mina, Harvey, Seneca E., Proctor, Deborah M., Rager, Julia E., Haws, Laurie C., Harris, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813206/
https://www.ncbi.nlm.nih.gov/pubmed/29064106
http://dx.doi.org/10.1002/jat.3545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813206/
https://www.ncbi.nlm.nih.gov/pubmed/29064106
http://dx.doi.org/10.1002/jat.3545

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