The Urokinase Receptor Induces a Mesenchymal Gene Expression Signature in Glioblastoma Cells and Promotes Tumor Cell Survival in Neurospheres

PLAUR encodes the urokinase receptor (uPAR), which promotes cell survival, migration, and resistance to targeted cancer therapeutics in glioblastoma cells in culture and in mouse model systems. Herein, we show that patient survival correlates inversely with PLAUR mRNA expression in gliomas of all gr...

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Detalles Bibliográficos
Autores principales: Gilder, Andrew S., Natali, Letizia, Van Dyk, Danielle M., Zalfa, Cristina, Banki, Michael A., Pizzo, Donald P., Wang, Huawei, Klemke, Richard L., Mantuano, Elisabetta, Gonias, Steven L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813209/
https://www.ncbi.nlm.nih.gov/pubmed/29445239
http://dx.doi.org/10.1038/s41598-018-21358-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813209/
https://www.ncbi.nlm.nih.gov/pubmed/29445239
http://dx.doi.org/10.1038/s41598-018-21358-1

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