RUNX‐mediated growth arrest and senescence are attenuated by diverse mechanisms in cells expressing RUNX1 fusion oncoproteins

RUNX gene over‐expression inhibits growth of primary cells but transforms cells with tumor suppressor defects, consistent with reported associations with tumor progression. In contrast, chromosomal translocations involving RUNX1 are detectable in utero, suggesting an initiating role in leukemias. Ho...

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Detalles Bibliográficos
Autores principales: Anderson, Gail, Mackay, Nancy, Gilroy, Kathryn, Hay, Jodie, Borland, Gillian, McDonald, Alma, Bell, Margaret, Hassanudin, Siti Ayuni, Cameron, Ewan, Neil, James C., Kilbey, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813226/
https://www.ncbi.nlm.nih.gov/pubmed/29052866
http://dx.doi.org/10.1002/jcb.26443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813226/
https://www.ncbi.nlm.nih.gov/pubmed/29052866
http://dx.doi.org/10.1002/jcb.26443

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