53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process

Chromosome missegregation acts as one of the driving forces for chromosome instability and cancer development. Here, we find that in human cancer cells, HeLa and U2OS, depletion of 53BP1 (p53-binding protein 1) exacerbates chromosome non-disjunction resulting from a new type of sister-chromatid inte...

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Detalles Bibliográficos
Autores principales: Tiwari, Ankana, Addis Jones, Owen, Chan, Kok-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813243/
https://www.ncbi.nlm.nih.gov/pubmed/29445165
http://dx.doi.org/10.1038/s41467-018-03098-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813243/
https://www.ncbi.nlm.nih.gov/pubmed/29445165
http://dx.doi.org/10.1038/s41467-018-03098-y

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