Saturation Mutagenesis by Efficient Free-Energy Calculation

[Image: see text] Single-point mutations in proteins can greatly influence protein stability, binding affinity, protein function or its expression per se. Here, we present accurate and efficient predictions of the free energy of mutation of amino acids. We divided the complete mutational free energy...

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Detalles Bibliográficos
Autores principales: Jandova, Zuzana, Fast, Daniel, Setz, Martina, Pechlaner, Maria, Oostenbrink, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813279/
https://www.ncbi.nlm.nih.gov/pubmed/29262673
http://dx.doi.org/10.1021/acs.jctc.7b01099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813279/
https://www.ncbi.nlm.nih.gov/pubmed/29262673
http://dx.doi.org/10.1021/acs.jctc.7b01099

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